The prevalence of human papillomavirus infection in Mombasa, Kenya

Hugo De Vuyst, Maria Rita Parisi, Andrew Karani, Kishor Mandaliya, Lucy Muchiri, Salvatore Vaccarella, Marleen Temmerman, Silvia Franceschi, Flavia Lillo

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Objectives: A human papillomavirus (HPV) prevalence survey was done in Mombasa, Kenya, to improve the knowledge of HPV prevalence and genotype distribution in sub-Saharan African countries overall, and in women of different ages. Methods: HPV prevalence was assessed using PCR in women older than 15 years attending family planning and mother-child care services. Results: Among 496 women, HPV prevalence was high (42.3%; 95% CI: 37.9-46.8; world age-standardized). Moreover, 46% of HPV-positive women harbored multiple-type infections. The most common types were HPV58 (10.5% of women), HPV16 (7.7%), HPV53 (6.7%), HPV18 (4.6%), and HPV6 (4.4%), and the prevalence of any high-risk HPV type was 28.8%. HPV prevalence was elevated among all age-groups (range 36.4-45.7%). Independent associations with HPV positivity were found for being in a polygamous marriage (OR = 1.7) and lifetime number of sexual partners (OR for ≥3 vs. 1 = 1.5), although they were of only borderline statistical significance. Conclusions: These findings differ from other world regions, showing a high HPV burden in all age-groups with a high proportion of multiple-type infections. Our data strengthen the urgency of HPV vaccination in Kenya but also highlight the elevated number of women who would have positive results in an HPV-based screening program in the country.

Original languageEnglish
Pages (from-to)2309-2313
Number of pages5
JournalCancer Causes and Control
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Keywords

  • Africa
  • Cervical cancer
  • Human papillomavirus prevalence
  • Kenya

Fingerprint

Dive into the research topics of 'The prevalence of human papillomavirus infection in Mombasa, Kenya'. Together they form a unique fingerprint.

Cite this