TY - JOUR
T1 - The prevalence of human papillomavirus infection in Mombasa, Kenya
AU - De Vuyst, Hugo
AU - Parisi, Maria Rita
AU - Karani, Andrew
AU - Mandaliya, Kishor
AU - Muchiri, Lucy
AU - Vaccarella, Salvatore
AU - Temmerman, Marleen
AU - Franceschi, Silvia
AU - Lillo, Flavia
N1 - Funding Information:
Acknowledgments The authors of the manuscript have no conflict of interest to declare. The authors would like to thank Dr. M.J. Othigo, Head of the Colposcopy Clinic of the Coast Provincial General Hospital. This work was supported by the European Commission (INCO-DG Research, contract number: ICA4-2001-10088) and the Bill and Melinda Gates Foundation (grant number 35537).
PY - 2010/12
Y1 - 2010/12
N2 - Objectives: A human papillomavirus (HPV) prevalence survey was done in Mombasa, Kenya, to improve the knowledge of HPV prevalence and genotype distribution in sub-Saharan African countries overall, and in women of different ages. Methods: HPV prevalence was assessed using PCR in women older than 15 years attending family planning and mother-child care services. Results: Among 496 women, HPV prevalence was high (42.3%; 95% CI: 37.9-46.8; world age-standardized). Moreover, 46% of HPV-positive women harbored multiple-type infections. The most common types were HPV58 (10.5% of women), HPV16 (7.7%), HPV53 (6.7%), HPV18 (4.6%), and HPV6 (4.4%), and the prevalence of any high-risk HPV type was 28.8%. HPV prevalence was elevated among all age-groups (range 36.4-45.7%). Independent associations with HPV positivity were found for being in a polygamous marriage (OR = 1.7) and lifetime number of sexual partners (OR for ≥3 vs. 1 = 1.5), although they were of only borderline statistical significance. Conclusions: These findings differ from other world regions, showing a high HPV burden in all age-groups with a high proportion of multiple-type infections. Our data strengthen the urgency of HPV vaccination in Kenya but also highlight the elevated number of women who would have positive results in an HPV-based screening program in the country.
AB - Objectives: A human papillomavirus (HPV) prevalence survey was done in Mombasa, Kenya, to improve the knowledge of HPV prevalence and genotype distribution in sub-Saharan African countries overall, and in women of different ages. Methods: HPV prevalence was assessed using PCR in women older than 15 years attending family planning and mother-child care services. Results: Among 496 women, HPV prevalence was high (42.3%; 95% CI: 37.9-46.8; world age-standardized). Moreover, 46% of HPV-positive women harbored multiple-type infections. The most common types were HPV58 (10.5% of women), HPV16 (7.7%), HPV53 (6.7%), HPV18 (4.6%), and HPV6 (4.4%), and the prevalence of any high-risk HPV type was 28.8%. HPV prevalence was elevated among all age-groups (range 36.4-45.7%). Independent associations with HPV positivity were found for being in a polygamous marriage (OR = 1.7) and lifetime number of sexual partners (OR for ≥3 vs. 1 = 1.5), although they were of only borderline statistical significance. Conclusions: These findings differ from other world regions, showing a high HPV burden in all age-groups with a high proportion of multiple-type infections. Our data strengthen the urgency of HPV vaccination in Kenya but also highlight the elevated number of women who would have positive results in an HPV-based screening program in the country.
KW - Africa
KW - Cervical cancer
KW - Human papillomavirus prevalence
KW - Kenya
UR - https://www.scopus.com/pages/publications/78751566501
U2 - 10.1007/s10552-010-9645-z
DO - 10.1007/s10552-010-9645-z
M3 - Article
C2 - 20938733
AN - SCOPUS:78751566501
SN - 0957-5243
VL - 21
SP - 2309
EP - 2313
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 12
ER -
