The prevalence of human papillomavirus infection in Mombassa, Kenya.

Hugo De Vuyst; Maria Rita Parisi; Andrew Karani; Kishor Mandaliya; Lucy Muchiri; Salvatore Vaccarella; Marleen Temmerman; Silvia Franceschi; Flavia Lillo

The prevalence of human papillomavirus infection in Mombassa, Kenya.

Hugo De Vuyst, Maria Rita Parisi, Andrew Karani, Kishor Mandaliya, Lucy Muchiri, Salvatore Vaccarella, Marleen Temmerman, Silvia Franceschi, Flavia Lillo

Centre of Excellence in Women and Child Health, East Africa

Research output: Contribution to journal › Article

Abstract

Objectives

A human papillomavirus (HPV) prevalence survey was done in Mombasa, Kenya, to improve the knowledge of HPV prevalence and genotype distribution in sub-Saharan African countries overall, and in women of different ages.

Methods

HPV prevalence was assessed using PCR in women older than 15 years attending family planning and mother–child care services.

Results

Among 496 women, HPV prevalence was high (42.3%; 95% CI: 37.9–46.8; world age-standardized). Moreover, 46% of HPV-positive women harbored multiple-type infections. The most common types were HPV58 (10.5% of women), HPV16 (7.7%), HPV53 (6.7%), HPV18 (4.6%), and HPV6 (4.4%), and the prevalence of any high-risk HPV type was 28.8%. HPV prevalence was elevated among all age-groups (range 36.4–45.7%). Independent associations with HPV positivity were found for being in a polygamous marriage (OR = 1.7) and lifetime number of sexual partners (OR for ≥3 vs. 1 = 1.5), although they were of only borderline statistical significance.

Conclusions

These findings differ from other world regions, showing a high HPV burden in all age-groups with a high proportion of multiple-type infections. Our data strengthen the urgency of HPV vaccination in Kenya but also highlight the elevated number of women who would have positive results in an HPV-based screening program in the country.

Original language	Undefined/Unknown
Journal	Obstetrics and Gynaecology, East Africa
Publication status	Published - 12 Oct 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

http://ecommons.aku.edu/eastafrica_fhs_mc_obstet_gynaecol/545

Cite this

@article{4120fd6e3e4849c69ab7e50914ce30f1,

title = "The prevalence of human papillomavirus infection in Mombassa, Kenya.",

abstract = "Objectives A human papillomavirus (HPV) prevalence survey was done in Mombasa, Kenya, to improve the knowledge of HPV prevalence and genotype distribution in sub-Saharan African countries overall, and in women of different ages. Methods HPV prevalence was assessed using PCR in women older than 15 years attending family planning and mother–child care services. Results Among 496 women, HPV prevalence was high (42.3%; 95% CI: 37.9–46.8; world age-standardized). Moreover, 46% of HPV-positive women harbored multiple-type infections. The most common types were HPV58 (10.5% of women), HPV16 (7.7%), HPV53 (6.7%), HPV18 (4.6%), and HPV6 (4.4%), and the prevalence of any high-risk HPV type was 28.8%. HPV prevalence was elevated among all age-groups (range 36.4–45.7%). Independent associations with HPV positivity were found for being in a polygamous marriage (OR = 1.7) and lifetime number of sexual partners (OR for ≥3 vs. 1 = 1.5), although they were of only borderline statistical significance. Conclusions These findings differ from other world regions, showing a high HPV burden in all age-groups with a high proportion of multiple-type infections. Our data strengthen the urgency of HPV vaccination in Kenya but also highlight the elevated number of women who would have positive results in an HPV-based screening program in the country.",

author = "Vuyst, {Hugo De} and Parisi, {Maria Rita} and Andrew Karani and Kishor Mandaliya and Lucy Muchiri and Salvatore Vaccarella and Marleen Temmerman and Silvia Franceschi and Flavia Lillo",

year = "2010",

month = oct,

day = "12",

language = "Undefined/Unknown",

journal = "Obstetrics and Gynaecology, East Africa",

}

TY - JOUR

T1 - The prevalence of human papillomavirus infection in Mombassa, Kenya.

AU - Vuyst, Hugo De

AU - Parisi, Maria Rita

AU - Karani, Andrew

AU - Mandaliya, Kishor

AU - Muchiri, Lucy

AU - Vaccarella, Salvatore

AU - Temmerman, Marleen

AU - Franceschi, Silvia

AU - Lillo, Flavia

PY - 2010/10/12

Y1 - 2010/10/12

N2 - Objectives A human papillomavirus (HPV) prevalence survey was done in Mombasa, Kenya, to improve the knowledge of HPV prevalence and genotype distribution in sub-Saharan African countries overall, and in women of different ages. Methods HPV prevalence was assessed using PCR in women older than 15 years attending family planning and mother–child care services. Results Among 496 women, HPV prevalence was high (42.3%; 95% CI: 37.9–46.8; world age-standardized). Moreover, 46% of HPV-positive women harbored multiple-type infections. The most common types were HPV58 (10.5% of women), HPV16 (7.7%), HPV53 (6.7%), HPV18 (4.6%), and HPV6 (4.4%), and the prevalence of any high-risk HPV type was 28.8%. HPV prevalence was elevated among all age-groups (range 36.4–45.7%). Independent associations with HPV positivity were found for being in a polygamous marriage (OR = 1.7) and lifetime number of sexual partners (OR for ≥3 vs. 1 = 1.5), although they were of only borderline statistical significance. Conclusions These findings differ from other world regions, showing a high HPV burden in all age-groups with a high proportion of multiple-type infections. Our data strengthen the urgency of HPV vaccination in Kenya but also highlight the elevated number of women who would have positive results in an HPV-based screening program in the country.

AB - Objectives A human papillomavirus (HPV) prevalence survey was done in Mombasa, Kenya, to improve the knowledge of HPV prevalence and genotype distribution in sub-Saharan African countries overall, and in women of different ages. Methods HPV prevalence was assessed using PCR in women older than 15 years attending family planning and mother–child care services. Results Among 496 women, HPV prevalence was high (42.3%; 95% CI: 37.9–46.8; world age-standardized). Moreover, 46% of HPV-positive women harbored multiple-type infections. The most common types were HPV58 (10.5% of women), HPV16 (7.7%), HPV53 (6.7%), HPV18 (4.6%), and HPV6 (4.4%), and the prevalence of any high-risk HPV type was 28.8%. HPV prevalence was elevated among all age-groups (range 36.4–45.7%). Independent associations with HPV positivity were found for being in a polygamous marriage (OR = 1.7) and lifetime number of sexual partners (OR for ≥3 vs. 1 = 1.5), although they were of only borderline statistical significance. Conclusions These findings differ from other world regions, showing a high HPV burden in all age-groups with a high proportion of multiple-type infections. Our data strengthen the urgency of HPV vaccination in Kenya but also highlight the elevated number of women who would have positive results in an HPV-based screening program in the country.

M3 - Article

JO - Obstetrics and Gynaecology, East Africa

JF - Obstetrics and Gynaecology, East Africa

ER -