The role of cepharanthine as an anti-atherosclerotic agent in rats

Adnan Iqbal, Rahila Najam, Saira Saeed Khan, Sumera Imran, Muhammad Osama, Anosh Tahir, Muhammad Imran, Bilal Jawed, Zeeshan Ahmed, Azfar Athar Ishaqui

Research output: Contribution to journalArticlepeer-review


This investigation assessed the potential of cepharanthine (CEP), a compound from Stephania cepharantha Hayata, in mitigating atherosclerosis in a hyperlipidemic rat model. Using Wistar rats, four distinct diet and drug treatment groups were established: a high-fat high sucrose diet (HFHS), HFHS supplemented with intraperitoneal cepharanthine (HFHS-C) or oral atorvastatin (HFHS-A) from the 8th week, and a normal-fat diet (NFD). The study aimed to evaluate diet and drug impact on aortic histopathological changes over 16 weeks. Our results revealed significant atherosclerosis prevention in the aorta of the HFHS-C group, marked by preserved endothelial integrity, absence of inflammation, and lack of atherosclerotic plaques. Additionally, CEP demonstrated a crucial role in preventing the emergence of cholesterol clefts and foamy macrophages. These findings suggest that CEP effectively curbs atherosclerosis progression in hyperlipidemic rats, reducing arterial fat deposition and offering a potential natural preventative strategy against this disease.

Original languageEnglish
Pages (from-to)1073-1077
Number of pages5
JournalPakistan Journal of Pharmaceutical Sciences
Issue number4
Publication statusPublished - Jul 2023
Externally publishedYes


  • ABCC10
  • atherosclerosis
  • cepharanthine
  • foamy macrophages
  • hyperlipidemia


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