The role of 18F-FDG PET/CT in evaluation of Primary CNS lymphoma: The path less travelled

Sharjeel Usmani; Anjali Jain; Khulood Al Riyami; Shah P. Naumani; Rashid Al-Sukaiti; Muhammad Shahzad Shamim

doi:10.47391/JPMA.23-59

The role of ¹⁸F-FDG PET/CT in evaluation of Primary CNS lymphoma: The path less travelled

Sharjeel Usmani, Anjali Jain, Khulood Al Riyami, Shah P. Naumani, Rashid Al-Sukaiti, Muhammad Shahzad Shamim

Department of Surgery, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare but highly aggressive lymphoma with increasing incidence in immunocompromised patients. MRI is the modality of choice in evaluating brain lesions. However, MRI is often challenging in the detection of early recurrence, assessing residual disease and response evaluation in PCNSL. ¹⁸F-FDG PET/CT has superior diagnostic performance compared with body CT in the evaluation of lymphoma. ¹⁸F-FDG PET-CT is helpful in evaluating evaluation of disease extent and differentiating primary CNS lymphoma from systemic lymphoma. Besides diagnostic and prognostic value in primary CNS lymphoma, it might also be helpful in response assessment. The role of FDG-PET in PCNSL is not fully defined. In this article we have reviewed the potential role of ¹⁸F-FDG PET/CT in initial diagnosis, baseline staging, restaging, evaluation of treatment response, prognostication, and survival analysis of PCNSL.

Original language	English
Pages (from-to)	1744-1746
Number of pages	3
Journal	Journal of the Pakistan Medical Association
Volume	73
Issue number	8
DOIs	https://doi.org/10.47391/JPMA.23-59
Publication status	Published - Aug 2023

Keywords

CNS lymphoma
F-FDG PET/CT
brain tumors

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title = "The role of 18F-FDG PET/CT in evaluation of Primary CNS lymphoma: The path less travelled",

abstract = "Primary central nervous system lymphoma (PCNSL) is a rare but highly aggressive lymphoma with increasing incidence in immunocompromised patients. MRI is the modality of choice in evaluating brain lesions. However, MRI is often challenging in the detection of early recurrence, assessing residual disease and response evaluation in PCNSL. 18F-FDG PET/CT has superior diagnostic performance compared with body CT in the evaluation of lymphoma. 18F-FDG PET-CT is helpful in evaluating evaluation of disease extent and differentiating primary CNS lymphoma from systemic lymphoma. Besides diagnostic and prognostic value in primary CNS lymphoma, it might also be helpful in response assessment. The role of FDG-PET in PCNSL is not fully defined. In this article we have reviewed the potential role of 18F-FDG PET/CT in initial diagnosis, baseline staging, restaging, evaluation of treatment response, prognostication, and survival analysis of PCNSL.",

keywords = "CNS lymphoma, F-FDG PET/CT, brain tumors",

author = "Sharjeel Usmani and Anjali Jain and {Al Riyami}, Khulood and Naumani, {Shah P.} and Rashid Al-Sukaiti and Shamim, {Muhammad Shahzad}",

year = "2023",

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T1 - The role of 18F-FDG PET/CT in evaluation of Primary CNS lymphoma

T2 - The path less travelled

AU - Usmani, Sharjeel

AU - Jain, Anjali

AU - Al Riyami, Khulood

AU - Naumani, Shah P.

AU - Al-Sukaiti, Rashid

AU - Shamim, Muhammad Shahzad

PY - 2023/8

Y1 - 2023/8

N2 - Primary central nervous system lymphoma (PCNSL) is a rare but highly aggressive lymphoma with increasing incidence in immunocompromised patients. MRI is the modality of choice in evaluating brain lesions. However, MRI is often challenging in the detection of early recurrence, assessing residual disease and response evaluation in PCNSL. 18F-FDG PET/CT has superior diagnostic performance compared with body CT in the evaluation of lymphoma. 18F-FDG PET-CT is helpful in evaluating evaluation of disease extent and differentiating primary CNS lymphoma from systemic lymphoma. Besides diagnostic and prognostic value in primary CNS lymphoma, it might also be helpful in response assessment. The role of FDG-PET in PCNSL is not fully defined. In this article we have reviewed the potential role of 18F-FDG PET/CT in initial diagnosis, baseline staging, restaging, evaluation of treatment response, prognostication, and survival analysis of PCNSL.

AB - Primary central nervous system lymphoma (PCNSL) is a rare but highly aggressive lymphoma with increasing incidence in immunocompromised patients. MRI is the modality of choice in evaluating brain lesions. However, MRI is often challenging in the detection of early recurrence, assessing residual disease and response evaluation in PCNSL. 18F-FDG PET/CT has superior diagnostic performance compared with body CT in the evaluation of lymphoma. 18F-FDG PET-CT is helpful in evaluating evaluation of disease extent and differentiating primary CNS lymphoma from systemic lymphoma. Besides diagnostic and prognostic value in primary CNS lymphoma, it might also be helpful in response assessment. The role of FDG-PET in PCNSL is not fully defined. In this article we have reviewed the potential role of 18F-FDG PET/CT in initial diagnosis, baseline staging, restaging, evaluation of treatment response, prognostication, and survival analysis of PCNSL.

KW - CNS lymphoma

KW - F-FDG PET/CT

KW - brain tumors

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ER -

The role of ¹⁸F-FDG PET/CT in evaluation of Primary CNS lymphoma: The path less travelled

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Keywords

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