The significance of mgmt methylation in glioblastoma multiforme prognosis

Aaida Mumtaz Rao, Ayesha Quddusi, Muhammad Shahzad Shamim

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

Methylation of O6-methylguanine-DNA methyltransferase (MGMT) has been extensively studied as a biomarker in predicting the prognosis of patients with GBM (Glioblastoma multiforme). Its significance has been studied in various subgroups, including age, gender and even race. Correlation between prognosis with MGMT methylation and different treatment regimens has also been studied in detail. There are multiple techniques to analyze MGMT methylation in tumour specimen. We review the current evidence for the importance of MGMT methylation as a biomarker for prognosis in GBM patients, the techniques to analyze it and the effect of epidemiologic factors on its significance.

Original languageEnglish
Pages (from-to)1137-1139
Number of pages3
JournalJournal of the Pakistan Medical Association
Volume68
Issue number7
Publication statusPublished - Jul 2018

Keywords

  • Glioblastoma multiforme
  • MGMT methylation
  • Tumour markers

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