Time-dependent in vivo mesolimbic dopamine variations following antigenic challenge

S. Lacosta, Z. Merali, S. Zalcman, H. Anisman

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Administration of sheep red blood cells (SRBC: 5 × 106) ro rats provoked an immune response which peaked 4 days following inoculation. Immune activation elicited an increase of in vivo extracellular dopamine (DA) in the nucleus accumbens, indicating increased release of DA from neurons. The DA alterations coincided with the time of the peak immune response, being significantly altered 4 days after inoculation, and declining to control levels thereafter. In contrast, the levels of serotonin metabolite, 5-hydroxyindoleacetic acid (5HIAA), were not affected by SRBC inoculation. These data are consistent with the supposition that antigenic challenge influences central neurotransmitters, and indicates that such effects are not restricted to the hypothalamus, but are apparent in mesolimbic regions. It is suggested that the antigenic challenge leads to effects comparable to those induced by stressors. As such, it might be expected that immune activation may come to produce behavioral alterations much like those engendered by stressors.

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalBrain Research
Issue number1-2
Publication statusPublished - 21 Nov 1994
Externally publishedYes


  • 5-Hydroxyindoleacetic acid
  • Dopamine
  • Homovanilic acid
  • Immune
  • Microdialysis


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