TY - JOUR
T1 - Time to establish an international vaccine candidate pool for potential highly infectious respiratory disease
T2 - a community's view
AU - Yao, Lan
AU - Chemaitelly, Hiam
AU - Goldman, Emanuel
AU - Gudina, Esayas Kebede
AU - Khalil, Asma
AU - Ahmed, Rahaman
AU - James, Ayorinde Babatunde
AU - Roca, Anna
AU - Fallah, Mosoka Papa
AU - Macnab, Andrew
AU - Cho, William C.
AU - Eikelboom, John
AU - Qamar, Farah Naz
AU - Kremsner, Peter
AU - Oliu-Barton, Miquel
AU - Sisa, Ivan
AU - Tadesse, Birkneh Tilahun
AU - Marks, Florian
AU - Wang, Lishi
AU - Kim, Jerome H.
AU - Meng, Xia
AU - Wang, Yongjun
AU - Fly, Alyce D.
AU - Wang, Cong Yi
AU - Day, Sara W.
AU - Howard, Scott C.
AU - Graff, J. Carolyn
AU - Maida, Marcello
AU - Ray, Kunal
AU - Franco-Paredes, Carlos
AU - Mashe, Tapfumanei
AU - Ngongo, Ngashi
AU - Kaseya, Jean
AU - Ndembi, Nicaise
AU - Hu, Yu
AU - Bottazzi, Maria Elena
AU - Hotez, Peter J.
AU - Ishii, Ken J.
AU - Wang, Gang
AU - Sun, Dianjun
AU - Aleya, Lotfi
AU - Gu, Weikuan
N1 - Publisher Copyright:
© 2023
PY - 2023/10
Y1 - 2023/10
N2 - In counteracting highly infectious and disruptive respiratory diseases such as COVID-19, vaccination remains the primary and safest way to prevent disease, reduce the severity of illness, and save lives. Unfortunately, vaccination is often not the first intervention deployed for a new pandemic, as it takes time to develop and test vaccines, and confirmation of safety requires a period of observation after vaccination to detect potential late-onset vaccine-associated adverse events. In the meantime, nonpharmacologic public health interventions such as mask-wearing and social distancing can provide some degree of protection. As climate change, with its environmental impacts on pathogen evolution and international mobility continue to rise, highly infectious respiratory diseases will likely emerge more frequently and their impact is expected to be substantial. How quickly a safe and efficacious vaccine can be deployed against rising infectious respiratory diseases may be the most important challenge that humanity will face in the near future. While some organizations are engaged in addressing the World Health Organization's “blueprint for priority diseases”, the lack of worldwide preparedness, and the uncertainty around universal vaccine availability, remain major concerns. We therefore propose the establishment of an international candidate vaccine pool repository for potential respiratory diseases, supported by multiple stakeholders and countries that contribute facilities, technologies, and other medical and financial resources. The types and categories of candidate vaccines can be determined based on information from previous pandemics and epidemics. Each participant country or region can focus on developing one or a few vaccine types or categories, together covering most if not all possible potential infectious diseases. The safety of these vaccines can be tested using animal models. Information for effective candidates that can be potentially applied to humans will then be shared across all participants. When a new pandemic arises, these pre-selected and tested vaccines can be quickly tested in RCTs for human populations.
AB - In counteracting highly infectious and disruptive respiratory diseases such as COVID-19, vaccination remains the primary and safest way to prevent disease, reduce the severity of illness, and save lives. Unfortunately, vaccination is often not the first intervention deployed for a new pandemic, as it takes time to develop and test vaccines, and confirmation of safety requires a period of observation after vaccination to detect potential late-onset vaccine-associated adverse events. In the meantime, nonpharmacologic public health interventions such as mask-wearing and social distancing can provide some degree of protection. As climate change, with its environmental impacts on pathogen evolution and international mobility continue to rise, highly infectious respiratory diseases will likely emerge more frequently and their impact is expected to be substantial. How quickly a safe and efficacious vaccine can be deployed against rising infectious respiratory diseases may be the most important challenge that humanity will face in the near future. While some organizations are engaged in addressing the World Health Organization's “blueprint for priority diseases”, the lack of worldwide preparedness, and the uncertainty around universal vaccine availability, remain major concerns. We therefore propose the establishment of an international candidate vaccine pool repository for potential respiratory diseases, supported by multiple stakeholders and countries that contribute facilities, technologies, and other medical and financial resources. The types and categories of candidate vaccines can be determined based on information from previous pandemics and epidemics. Each participant country or region can focus on developing one or a few vaccine types or categories, together covering most if not all possible potential infectious diseases. The safety of these vaccines can be tested using animal models. Information for effective candidates that can be potentially applied to humans will then be shared across all participants. When a new pandemic arises, these pre-selected and tested vaccines can be quickly tested in RCTs for human populations.
KW - COVID-19
KW - Disease
KW - Infection
KW - International collaboration
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=85171975476&partnerID=8YFLogxK
U2 - 10.1016/j.eclinm.2023.102222
DO - 10.1016/j.eclinm.2023.102222
M3 - Review article
AN - SCOPUS:85171975476
SN - 2589-5370
VL - 64
JO - eClinicalMedicine
JF - eClinicalMedicine
M1 - 102222
ER -