TY - JOUR
T1 - Total skin electron beam therapy (TSEBT) in management of mycosis fungoides
T2 - A case series
AU - Abrar, Sehrish
AU - Qureshi, Bilal Mazhar
AU - Hafiz, Asim
AU - Ali, Nasir
AU - Khan, Agha Mohammad Hammad
AU - Abbasi, Ahmed Nadeem
N1 - Publisher Copyright:
© 2022 Pakistan Medical Association. All rights reserved.
PY - 2022/6
Y1 - 2022/6
N2 - A retrospective review was conducted In Aga Khan University from January 2013-December 2020 for patients who received Total Skin Electron Beam Therapy (TSEBT) on the management of Mycosis Fungoides (MF). The clinical response rate and disease-free interval (DFI) was evaluated for three patients. All of the patients received a 3600 cGy dose of radiation. Clinical complete remission (cCR) was observed in two out of three patients, while one patient showed clinical partial response. Following the cCR to TSEBT, the DFI of the first patient with stage 1B lasted 30 months, while the second patient with stage IIB remained disease free for five months. TSEBT is an effective treatment for MF disease. It can thus be expected that patients with limited disease in the early stage can acquire a cCR with a longer DFI. The clinical outcomes of our study show concordance with the literature. The patients who had extensive (T3) skin involvement and had refractory diseases showed lower DFI with radiation.
AB - A retrospective review was conducted In Aga Khan University from January 2013-December 2020 for patients who received Total Skin Electron Beam Therapy (TSEBT) on the management of Mycosis Fungoides (MF). The clinical response rate and disease-free interval (DFI) was evaluated for three patients. All of the patients received a 3600 cGy dose of radiation. Clinical complete remission (cCR) was observed in two out of three patients, while one patient showed clinical partial response. Following the cCR to TSEBT, the DFI of the first patient with stage 1B lasted 30 months, while the second patient with stage IIB remained disease free for five months. TSEBT is an effective treatment for MF disease. It can thus be expected that patients with limited disease in the early stage can acquire a cCR with a longer DFI. The clinical outcomes of our study show concordance with the literature. The patients who had extensive (T3) skin involvement and had refractory diseases showed lower DFI with radiation.
KW - Clinical Response Rate
KW - Disease-free interval
KW - Modified Stanford technique
KW - Mycosis Fungoides
KW - Total skin electron beam therapy
UR - http://www.scopus.com/inward/record.url?scp=85131258074&partnerID=8YFLogxK
U2 - 10.47391/JPMA.3784
DO - 10.47391/JPMA.3784
M3 - Article
C2 - 35751338
AN - SCOPUS:85131258074
SN - 0030-9982
VL - 72
SP - 1208
EP - 1210
JO - Journal of the Pakistan Medical Association
JF - Journal of the Pakistan Medical Association
IS - 6
ER -