Trabectome (trabeculectomy - internal approach): Additional experience and extended follow-up

Don Minckler; Sameh Mosaed; Laurie Dustin; Brian Francis; D. Apte; R. E. Bandel; R. Shetty; E. M. Barnett; C. Batiste; D. Budenz; T. Chen; D. Rhee; R. L. Chevrier; K. Damji; D. Marshall; J. Compagna; F. Cotter; N. Donas; R. Fellman; D. Friedman; Z. Ghiasi; C. Girkin; D. Godfrey; A. Jamil; M. Johnstone; R. Mills; L. S. Jones; Y. H. Kwon; D. Laroche; M. Leen; M. Maeda; B. B. Mahan; K. Mitchell; Q. Nguyen; G. Osmundson; C. Patitsas; M. Ramirez; G. Reiss; R. Rosenquist; J. Schuman; P. Sidoti; C. J. Siegfried; A. Sit; M. Stiles; R. Tamesis; T. Tanji; J. Trible; S. D. Vold; M. Watanabe; R. Weinreb; P. T. Zacharia

Trabectome (trabeculectomy - internal approach): Additional experience and extended follow-up

Don Minckler, Sameh Mosaed, Laurie Dustin, Brian Francis, D. Apte, R. E. Bandel, R. Shetty, E. M. Barnett, C. Batiste, D. Budenz, T. Chen, D. Rhee, R. L. Chevrier, K. Damji, D. Marshall, J. Compagna, F. Cotter, N. Donas, R. Fellman, D. FriedmanZ. Ghiasi, C. Girkin, D. Godfrey, A. Jamil, M. Johnstone, R. Mills, L. S. Jones, Y. H. Kwon, D. Laroche, M. Leen, M. Maeda, B. B. Mahan, K. Mitchell, Q. Nguyen, G. Osmundson, C. Patitsas, M. Ramirez, G. Reiss, R. Rosenquist, J. Schuman, P. Sidoti, C. J. Siegfried, A. Sit, M. Stiles, R. Tamesis, T. Tanji, J. Trible, S. D. Vold, M. Watanabe, R. Weinreb, P. T. Zacharia

Research output: Contribution to journal › Article › peer-review

173 Citations (Scopus)

Abstract

Purpose: To report a retrospective case series of 1127 Trabectome surgical procedures, including 738 Trabectome-only and 366 Trabectome-phacoemulsification surgeries. Methods: Electroablation of meshwork via a temporal corneal incision. Outcomes included changes in intraocular pressure (IOP) and medication use, complications, and Kaplan-Meier success estimates. Results: For all cases, mean preoperative IOP of 23.8 ± 7.7 mm Hg decreased by 39% to 16.5 ± 4.0 mm Hg at 24 months (n = 50). Intraoperative reflux bleeding occurred in 77.6%. Medications decreased from 2.8 to 1.2 by 24 months. Sixty-five patients (5.8%) had IOP elevation > 10 mm Hg above baseline on day 1. Failure led to trabeculectomy in 5.9% (n = 67) and shunt installation in 1.6% (n = 18). Kaplan-Meier failure was defined across groups with at least 2 weeks follow-up as IOP > 21 mm Hg with or without medications and not reduced by 20% below baseline on 2 consecutive visits or repeat surgery. For Trabectome-only cases, mean preoperative IOP of 25.7 ± 7.7 mm Hg was reduced by 40% to 16.6 ± 4.0 mm Hg at 24 months (n = 46). No prolonged hypotony, choroidal effusion, choroidal hemorrhage, or infections occurred. Failure led to trabeculectomy in 8.1% (n = 60) and shunt installation in 1.9% (n = 14). Medications decreased from 2.93 to 1.2 by 24 months. For Trabectome-phacoemulsification cases, baseline IOP of 20.0 ± 6.2 mm Hg decreased at 12 months to 15.9 ± 3.3 mm Hg (18%) (n = 45) and medications decreased from 2.63 ± 1.12 to 1.50 ± 1.36. Sixteen (4.4%) of 365 had prior failed trabeculectomy, and 139 of 365 (38%) had prior laser trabeculoplasty. Conclusion: Trabectome offers a minimally invasive method of improving IOP control in open-angle glaucomas.

Original language	English
Pages (from-to)	149-159
Number of pages	11
Journal	Transactions of the American Ophthalmological Society
Volume	106
Publication status	Published - 2008
Externally published	Yes

Cite this

Minckler, D., Mosaed, S., Dustin, L., Francis, B., Apte, D., Bandel, R. E., Shetty, R., Barnett, E. M., Batiste, C., Budenz, D., Chen, T., Rhee, D., Chevrier, R. L., Damji, K., Marshall, D., Compagna, J., Cotter, F., Donas, N., Fellman, R., ... Zacharia, P. T. (2008). Trabectome (trabeculectomy - internal approach): Additional experience and extended follow-up. Transactions of the American Ophthalmological Society, 106, 149-159.

@article{185e01dd15074ea2a6d061d8c0bfb175,

title = "Trabectome (trabeculectomy - internal approach): Additional experience and extended follow-up",

abstract = "Purpose: To report a retrospective case series of 1127 Trabectome surgical procedures, including 738 Trabectome-only and 366 Trabectome-phacoemulsification surgeries. Methods: Electroablation of meshwork via a temporal corneal incision. Outcomes included changes in intraocular pressure (IOP) and medication use, complications, and Kaplan-Meier success estimates. Results: For all cases, mean preoperative IOP of 23.8 ± 7.7 mm Hg decreased by 39% to 16.5 ± 4.0 mm Hg at 24 months (n = 50). Intraoperative reflux bleeding occurred in 77.6%. Medications decreased from 2.8 to 1.2 by 24 months. Sixty-five patients (5.8%) had IOP elevation > 10 mm Hg above baseline on day 1. Failure led to trabeculectomy in 5.9% (n = 67) and shunt installation in 1.6% (n = 18). Kaplan-Meier failure was defined across groups with at least 2 weeks follow-up as IOP > 21 mm Hg with or without medications and not reduced by 20% below baseline on 2 consecutive visits or repeat surgery. For Trabectome-only cases, mean preoperative IOP of 25.7 ± 7.7 mm Hg was reduced by 40% to 16.6 ± 4.0 mm Hg at 24 months (n = 46). No prolonged hypotony, choroidal effusion, choroidal hemorrhage, or infections occurred. Failure led to trabeculectomy in 8.1% (n = 60) and shunt installation in 1.9% (n = 14). Medications decreased from 2.93 to 1.2 by 24 months. For Trabectome-phacoemulsification cases, baseline IOP of 20.0 ± 6.2 mm Hg decreased at 12 months to 15.9 ± 3.3 mm Hg (18%) (n = 45) and medications decreased from 2.63 ± 1.12 to 1.50 ± 1.36. Sixteen (4.4%) of 365 had prior failed trabeculectomy, and 139 of 365 (38%) had prior laser trabeculoplasty. Conclusion: Trabectome offers a minimally invasive method of improving IOP control in open-angle glaucomas.",

author = "Don Minckler and Sameh Mosaed and Laurie Dustin and Brian Francis and D. Apte and Bandel, {R. E.} and R. Shetty and Barnett, {E. M.} and C. Batiste and D. Budenz and T. Chen and D. Rhee and Chevrier, {R. L.} and K. Damji and D. Marshall and J. Compagna and F. Cotter and N. Donas and R. Fellman and D. Friedman and Z. Ghiasi and C. Girkin and D. Godfrey and A. Jamil and M. Johnstone and R. Mills and Jones, {L. S.} and Kwon, {Y. H.} and D. Laroche and M. Leen and M. Maeda and Mahan, {B. B.} and K. Mitchell and Q. Nguyen and G. Osmundson and C. Patitsas and M. Ramirez and G. Reiss and R. Rosenquist and J. Schuman and P. Sidoti and Siegfried, {C. J.} and A. Sit and M. Stiles and R. Tamesis and T. Tanji and J. Trible and Vold, {S. D.} and M. Watanabe and R. Weinreb and Zacharia, {P. T.}",

year = "2008",

language = "English",

volume = "106",

pages = "149--159",

journal = "Transactions of the American Ophthalmological Society",

issn = "0065-9533",

publisher = "American Ophthalmological Society",

}

Minckler, D, Mosaed, S, Dustin, L, Francis, B, Apte, D, Bandel, RE, Shetty, R, Barnett, EM, Batiste, C, Budenz, D, Chen, T, Rhee, D, Chevrier, RL, Damji, K, Marshall, D, Compagna, J, Cotter, F, Donas, N, Fellman, R, Friedman, D, Ghiasi, Z, Girkin, C, Godfrey, D, Jamil, A, Johnstone, M, Mills, R, Jones, LS, Kwon, YH, Laroche, D, Leen, M, Maeda, M, Mahan, BB, Mitchell, K, Nguyen, Q, Osmundson, G, Patitsas, C, Ramirez, M, Reiss, G, Rosenquist, R, Schuman, J, Sidoti, P, Siegfried, CJ, Sit, A, Stiles, M, Tamesis, R, Tanji, T, Trible, J, Vold, SD, Watanabe, M, Weinreb, R & Zacharia, PT 2008, 'Trabectome (trabeculectomy - internal approach): Additional experience and extended follow-up', Transactions of the American Ophthalmological Society, vol. 106, pp. 149-159.

TY - JOUR

T1 - Trabectome (trabeculectomy - internal approach)

T2 - Additional experience and extended follow-up

AU - Minckler, Don

AU - Mosaed, Sameh

AU - Dustin, Laurie

AU - Francis, Brian

AU - Apte, D.

AU - Bandel, R. E.

AU - Shetty, R.

AU - Barnett, E. M.

AU - Batiste, C.

AU - Budenz, D.

AU - Chen, T.

AU - Rhee, D.

AU - Chevrier, R. L.

AU - Damji, K.

AU - Marshall, D.

AU - Compagna, J.

AU - Cotter, F.

AU - Donas, N.

AU - Fellman, R.

AU - Friedman, D.

AU - Ghiasi, Z.

AU - Girkin, C.

AU - Godfrey, D.

AU - Jamil, A.

AU - Johnstone, M.

AU - Mills, R.

AU - Jones, L. S.

AU - Kwon, Y. H.

AU - Laroche, D.

AU - Leen, M.

AU - Maeda, M.

AU - Mahan, B. B.

AU - Mitchell, K.

AU - Nguyen, Q.

AU - Osmundson, G.

AU - Patitsas, C.

AU - Ramirez, M.

AU - Reiss, G.

AU - Rosenquist, R.

AU - Schuman, J.

AU - Sidoti, P.

AU - Siegfried, C. J.

AU - Sit, A.

AU - Stiles, M.

AU - Tamesis, R.

AU - Tanji, T.

AU - Trible, J.

AU - Vold, S. D.

AU - Watanabe, M.

AU - Weinreb, R.

AU - Zacharia, P. T.

PY - 2008

Y1 - 2008

N2 - Purpose: To report a retrospective case series of 1127 Trabectome surgical procedures, including 738 Trabectome-only and 366 Trabectome-phacoemulsification surgeries. Methods: Electroablation of meshwork via a temporal corneal incision. Outcomes included changes in intraocular pressure (IOP) and medication use, complications, and Kaplan-Meier success estimates. Results: For all cases, mean preoperative IOP of 23.8 ± 7.7 mm Hg decreased by 39% to 16.5 ± 4.0 mm Hg at 24 months (n = 50). Intraoperative reflux bleeding occurred in 77.6%. Medications decreased from 2.8 to 1.2 by 24 months. Sixty-five patients (5.8%) had IOP elevation > 10 mm Hg above baseline on day 1. Failure led to trabeculectomy in 5.9% (n = 67) and shunt installation in 1.6% (n = 18). Kaplan-Meier failure was defined across groups with at least 2 weeks follow-up as IOP > 21 mm Hg with or without medications and not reduced by 20% below baseline on 2 consecutive visits or repeat surgery. For Trabectome-only cases, mean preoperative IOP of 25.7 ± 7.7 mm Hg was reduced by 40% to 16.6 ± 4.0 mm Hg at 24 months (n = 46). No prolonged hypotony, choroidal effusion, choroidal hemorrhage, or infections occurred. Failure led to trabeculectomy in 8.1% (n = 60) and shunt installation in 1.9% (n = 14). Medications decreased from 2.93 to 1.2 by 24 months. For Trabectome-phacoemulsification cases, baseline IOP of 20.0 ± 6.2 mm Hg decreased at 12 months to 15.9 ± 3.3 mm Hg (18%) (n = 45) and medications decreased from 2.63 ± 1.12 to 1.50 ± 1.36. Sixteen (4.4%) of 365 had prior failed trabeculectomy, and 139 of 365 (38%) had prior laser trabeculoplasty. Conclusion: Trabectome offers a minimally invasive method of improving IOP control in open-angle glaucomas.

AB - Purpose: To report a retrospective case series of 1127 Trabectome surgical procedures, including 738 Trabectome-only and 366 Trabectome-phacoemulsification surgeries. Methods: Electroablation of meshwork via a temporal corneal incision. Outcomes included changes in intraocular pressure (IOP) and medication use, complications, and Kaplan-Meier success estimates. Results: For all cases, mean preoperative IOP of 23.8 ± 7.7 mm Hg decreased by 39% to 16.5 ± 4.0 mm Hg at 24 months (n = 50). Intraoperative reflux bleeding occurred in 77.6%. Medications decreased from 2.8 to 1.2 by 24 months. Sixty-five patients (5.8%) had IOP elevation > 10 mm Hg above baseline on day 1. Failure led to trabeculectomy in 5.9% (n = 67) and shunt installation in 1.6% (n = 18). Kaplan-Meier failure was defined across groups with at least 2 weeks follow-up as IOP > 21 mm Hg with or without medications and not reduced by 20% below baseline on 2 consecutive visits or repeat surgery. For Trabectome-only cases, mean preoperative IOP of 25.7 ± 7.7 mm Hg was reduced by 40% to 16.6 ± 4.0 mm Hg at 24 months (n = 46). No prolonged hypotony, choroidal effusion, choroidal hemorrhage, or infections occurred. Failure led to trabeculectomy in 8.1% (n = 60) and shunt installation in 1.9% (n = 14). Medications decreased from 2.93 to 1.2 by 24 months. For Trabectome-phacoemulsification cases, baseline IOP of 20.0 ± 6.2 mm Hg decreased at 12 months to 15.9 ± 3.3 mm Hg (18%) (n = 45) and medications decreased from 2.63 ± 1.12 to 1.50 ± 1.36. Sixteen (4.4%) of 365 had prior failed trabeculectomy, and 139 of 365 (38%) had prior laser trabeculoplasty. Conclusion: Trabectome offers a minimally invasive method of improving IOP control in open-angle glaucomas.

UR - http://www.scopus.com/inward/record.url?scp=62849090894&partnerID=8YFLogxK

M3 - Article

C2 - 19277230

AN - SCOPUS:62849090894

SN - 0065-9533

VL - 106

SP - 149

EP - 159

JO - Transactions of the American Ophthalmological Society

JF - Transactions of the American Ophthalmological Society

ER -

Trabectome (trabeculectomy - internal approach): Additional experience and extended follow-up

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