Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity

Zimu Wu; Robyn L. Woods; Rory Wolfe; Elsdon Storey; Trevor T.J. Chong; Raj C. Shah; Suzanne G. Orchard; John J. McNeil; Anne M. Murray; Joanne Ryan

doi:10.1002/dad2.12180

Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity

Zimu Wu
, Robyn L. Woods
, Rory Wolfe
, Elsdon Storey
, Trevor T.J. Chong
, Raj C. Shah
, Suzanne G. Orchard
, John J. McNeil
, Anne M. Murray
, Joanne Ryan

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Introduction: This study aimed to investigate cognitive aging trajectories, the associated sociodemographic characteristics, and the association of these trajectories with dementia. Methods: Generally healthy older adults (n = 19,114) were followed for up to 7 years, with regular cognitive assessments. Group-based trajectory modeling identified distinct cognitive trajectories. Results: Four to seven trajectories were identified per cognitive domain. Stable trajectories were observed across domains. Improvement in verbal fluency and minor psy-chomotor slowing were common. Substantial decline in global cognition and episodic memory were observed in a small proportion of individuals. Older, less educated participants and men were more common in lower-functioning trajectories (p < .001). The highest proportions of dementia cases were in trajectories with major decline in global cognition (56.9%) and memory (33.2%). Discussion: Inter-individual variability in cognitive trajectories was observed across all domains. Some individuals appear resilient to cognitive decline even with advancing age. Further research into factors promoting cognitive resilience is needed.

Original language	English (US)
Article number	e12180
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	13
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12180
Publication status	Published - 2021
Externally published	Yes

Keywords

Cognitive function
Dementia
Longitudinal
Older adults
Prospective

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/dad2.12180

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Wu, Z., Woods, R. L., Wolfe, R., Storey, E., Chong, T. T. J., Shah, R. C., Orchard, S. G., McNeil, J. J., Murray, A. M., & Ryan, J. (2021). Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 13(1), Article e12180. https://doi.org/10.1002/dad2.12180

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title = "Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity",

abstract = "Introduction: This study aimed to investigate cognitive aging trajectories, the associated sociodemographic characteristics, and the association of these trajectories with dementia. Methods: Generally healthy older adults (n = 19,114) were followed for up to 7 years, with regular cognitive assessments. Group-based trajectory modeling identified distinct cognitive trajectories. Results: Four to seven trajectories were identified per cognitive domain. Stable trajectories were observed across domains. Improvement in verbal fluency and minor psy-chomotor slowing were common. Substantial decline in global cognition and episodic memory were observed in a small proportion of individuals. Older, less educated participants and men were more common in lower-functioning trajectories (p < .001). The highest proportions of dementia cases were in trajectories with major decline in global cognition (56.9\%) and memory (33.2\%). Discussion: Inter-individual variability in cognitive trajectories was observed across all domains. Some individuals appear resilient to cognitive decline even with advancing age. Further research into factors promoting cognitive resilience is needed.",

keywords = "Cognitive function, Dementia, Longitudinal, Older adults, Prospective",

author = "Zimu Wu and Woods, \{Robyn L.\} and Rory Wolfe and Elsdon Storey and Chong, \{Trevor T.J.\} and Shah, \{Raj C.\} and Orchard, \{Suzanne G.\} and McNeil, \{John J.\} and Murray, \{Anne M.\} and Joanne Ryan",

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year = "2021",

doi = "10.1002/dad2.12180",

language = "English (US)",

volume = "13",

journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

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TY - JOUR

T1 - Trajectories of cognitive function in community-dwelling older adults

T2 - A longitudinal study of population heterogeneity

AU - Wu, Zimu

AU - Woods, Robyn L.

AU - Wolfe, Rory

AU - Storey, Elsdon

AU - Chong, Trevor T.J.

AU - Shah, Raj C.

AU - Orchard, Suzanne G.

AU - McNeil, John J.

AU - Murray, Anne M.

AU - Ryan, Joanne

PY - 2021

Y1 - 2021

N2 - Introduction: This study aimed to investigate cognitive aging trajectories, the associated sociodemographic characteristics, and the association of these trajectories with dementia. Methods: Generally healthy older adults (n = 19,114) were followed for up to 7 years, with regular cognitive assessments. Group-based trajectory modeling identified distinct cognitive trajectories. Results: Four to seven trajectories were identified per cognitive domain. Stable trajectories were observed across domains. Improvement in verbal fluency and minor psy-chomotor slowing were common. Substantial decline in global cognition and episodic memory were observed in a small proportion of individuals. Older, less educated participants and men were more common in lower-functioning trajectories (p < .001). The highest proportions of dementia cases were in trajectories with major decline in global cognition (56.9%) and memory (33.2%). Discussion: Inter-individual variability in cognitive trajectories was observed across all domains. Some individuals appear resilient to cognitive decline even with advancing age. Further research into factors promoting cognitive resilience is needed.

AB - Introduction: This study aimed to investigate cognitive aging trajectories, the associated sociodemographic characteristics, and the association of these trajectories with dementia. Methods: Generally healthy older adults (n = 19,114) were followed for up to 7 years, with regular cognitive assessments. Group-based trajectory modeling identified distinct cognitive trajectories. Results: Four to seven trajectories were identified per cognitive domain. Stable trajectories were observed across domains. Improvement in verbal fluency and minor psy-chomotor slowing were common. Substantial decline in global cognition and episodic memory were observed in a small proportion of individuals. Older, less educated participants and men were more common in lower-functioning trajectories (p < .001). The highest proportions of dementia cases were in trajectories with major decline in global cognition (56.9%) and memory (33.2%). Discussion: Inter-individual variability in cognitive trajectories was observed across all domains. Some individuals appear resilient to cognitive decline even with advancing age. Further research into factors promoting cognitive resilience is needed.

KW - Cognitive function

KW - Dementia

KW - Longitudinal

KW - Older adults

KW - Prospective

UR - https://www.scopus.com/pages/publications/85108248690

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DO - 10.1002/dad2.12180

M3 - Article

AN - SCOPUS:85108248690

SN - 2352-8729

VL - 13

JO - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

JF - Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

IS - 1

M1 - e12180

ER -

Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity

Abstract

Keywords

UN SDGs

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