Transatlantic guidelines on dyslipidemia and cardiovascular risk: Key differences across the pond

Ali M. Agha, Salim S. Virani, Christie M. Ballantyne

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Purpose of reviewThe purpose of this review is to compare and contrast the key messages from the 2018 American Heart Association (AHA)/American College of Cardiology (ACC) Multisociety Guideline on the Management of Blood Cholesterol and the 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) Guidelines for the Management of Dyslipidemias. We also review some of the evidence that served as the basis for these guidelines and share our opinion regarding these guidelines.Recent findingsPatients with atherosclerotic cardiovascular disease (ASCVD), severe hypercholesterolemia, familial hypercholesterolemia, or diabetes should be treated aggressively with lipid-lowering therapy. In addition to traditional risk factors included in risk scores, assessment of risk enhancers/modifiers may improve risk stratification. The addition of ezetimibe ± proprotein convertase subtilisin/kexin type 9 inhibitors plays an integral role in the management of very-high-risk ASCVD patients; the ESC/EAS guidelines support more aggressive use of these medications.SummaryBoth the AHA/ACC Multisociety and ESC/EAS guidelines provide an evidence-based approach to management of blood cholesterol. The greatest difference between these two guidelines is the classification and recommended management of very-high-risk patients. Implementation of either guideline will likely lead to improved ASCVD outcomes compared with current treatment practice.Video abstract

Original languageEnglish
Pages (from-to)114-121
Number of pages8
JournalCurrent Opinion in Endocrinology, Diabetes and Obesity
Issue number2
Publication statusPublished - 1 Apr 2021
Externally publishedYes


  • atherosclerotic cardiovascular disease
  • cholesterol
  • hyperlipidemia
  • risk stratification


Dive into the research topics of 'Transatlantic guidelines on dyslipidemia and cardiovascular risk: Key differences across the pond'. Together they form a unique fingerprint.

Cite this