TY - JOUR
T1 - Trends of hematopoietic stem cell transplantation in the Eastern Mediterranean region, 1984-2007
AU - Ahmed, Syed O.A.
AU - Ghavamzadeh, Ardeshir
AU - Zaidi, Syed Z.
AU - Baldomero, Helen
AU - Pasquini, Marcelo C.
AU - Hussain, Fazal
AU - Alimoghaddam, Kamran
AU - Almohareb, Fahad
AU - Ayas, Mouhab
AU - Hamidieh, Amir
AU - Mahmoud, Hossam K.
AU - Elhaddad, Alaa
AU - Ben Othman, Tarek
AU - Abdelkefi, Abdelrahman
AU - Sarhan, Mahmoud
AU - Abdel-Rahman, Fawzi
AU - Adil, Salman
AU - Alkindi, Salam
AU - Bazarbachi, Ali
AU - Benchekroun, Said
AU - Niederwieser, Dietger
AU - Horowitz, Mary
AU - Gratwohl, Alois
AU - El Solh, Hassan
AU - Aljurf, Mahmoud
PY - 2011/9
Y1 - 2011/9
N2 - Hematopoietic stem cell transplantation (HSCT) activity was surveyed in the 9 countries in the World Health Organization Eastern Mediterranean region that reported transplantation activity. Between the years of 1984 and 2007, 7933 transplantations were performed. The number of HSCTs per year has continued to increase, with a plateau in allogeneic HSCT (allo-HSCT) between 2005 and 2007. Overall, a greater proportion of transplantations were allo-HSCT (n = 5761, 77%) compared with autologous HSCT (ASCT) (n = 2172, 23%). Of 5761 allo-HSCT, acute leukemia constituted the main indication (n = 2124, 37%). There was a significant proportion of allo-HSCT for bone marrow failures (n = 1001, 17%) and hemoglobinopathies (n = 885, 15%). The rate of unrelated donor transplantations remained low, with only 2 matched unrelated donor allo-HSCTs reported. One hundred umbilical cord blood transplantations were reported (0.017% of allo-HSCT). Peripheral blood stem cells were the main source of graft in allo-HSCT, and peripheral blood stem cells increasingly constitute the main source of hematopoietic stem cells overall. Reduced-intensity conditioning was utilized in 5.7% of allografts over the surveyed period. ASCT numbers continue to increase. There has been a shift in the indication for ASCT from acute leukemia to lymphoproliferative disorders (45%), followed by myeloma (26%). The survey reflects transplantation activity according to the unique health settings of this region. Notable differences in transplantation practices as reported to the European Group for Blood and Marrow Transplantation over recent years are highlighted.
AB - Hematopoietic stem cell transplantation (HSCT) activity was surveyed in the 9 countries in the World Health Organization Eastern Mediterranean region that reported transplantation activity. Between the years of 1984 and 2007, 7933 transplantations were performed. The number of HSCTs per year has continued to increase, with a plateau in allogeneic HSCT (allo-HSCT) between 2005 and 2007. Overall, a greater proportion of transplantations were allo-HSCT (n = 5761, 77%) compared with autologous HSCT (ASCT) (n = 2172, 23%). Of 5761 allo-HSCT, acute leukemia constituted the main indication (n = 2124, 37%). There was a significant proportion of allo-HSCT for bone marrow failures (n = 1001, 17%) and hemoglobinopathies (n = 885, 15%). The rate of unrelated donor transplantations remained low, with only 2 matched unrelated donor allo-HSCTs reported. One hundred umbilical cord blood transplantations were reported (0.017% of allo-HSCT). Peripheral blood stem cells were the main source of graft in allo-HSCT, and peripheral blood stem cells increasingly constitute the main source of hematopoietic stem cells overall. Reduced-intensity conditioning was utilized in 5.7% of allografts over the surveyed period. ASCT numbers continue to increase. There has been a shift in the indication for ASCT from acute leukemia to lymphoproliferative disorders (45%), followed by myeloma (26%). The survey reflects transplantation activity according to the unique health settings of this region. Notable differences in transplantation practices as reported to the European Group for Blood and Marrow Transplantation over recent years are highlighted.
KW - Conditioning
KW - EMRO
KW - Hematopoietic stem cell transplantation
KW - Stem cell source
UR - http://www.scopus.com/inward/record.url?scp=79961002454&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2011.01.019
DO - 10.1016/j.bbmt.2011.01.019
M3 - Article
C2 - 21440654
AN - SCOPUS:79961002454
SN - 1083-8791
VL - 17
SP - 1352
EP - 1361
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 9
ER -