Trends of hematopoietic stem cell transplantation in the Eastern Mediterranean region, 1984-2007

Syed O.A. Ahmed, Ardeshir Ghavamzadeh, Syed Z. Zaidi, Helen Baldomero, Marcelo C. Pasquini, Fazal Hussain, Kamran Alimoghaddam, Fahad Almohareb, Mouhab Ayas, Amir Hamidieh, Hossam K. Mahmoud, Alaa Elhaddad, Tarek Ben Othman, Abdelrahman Abdelkefi, Mahmoud Sarhan, Fawzi Abdel-Rahman, Salman Adil, Salam Alkindi, Ali Bazarbachi, Said BenchekrounDietger Niederwieser, Mary Horowitz, Alois Gratwohl, Hassan El Solh, Mahmoud Aljurf

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Hematopoietic stem cell transplantation (HSCT) activity was surveyed in the 9 countries in the World Health Organization Eastern Mediterranean region that reported transplantation activity. Between the years of 1984 and 2007, 7933 transplantations were performed. The number of HSCTs per year has continued to increase, with a plateau in allogeneic HSCT (allo-HSCT) between 2005 and 2007. Overall, a greater proportion of transplantations were allo-HSCT (n = 5761, 77%) compared with autologous HSCT (ASCT) (n = 2172, 23%). Of 5761 allo-HSCT, acute leukemia constituted the main indication (n = 2124, 37%). There was a significant proportion of allo-HSCT for bone marrow failures (n = 1001, 17%) and hemoglobinopathies (n = 885, 15%). The rate of unrelated donor transplantations remained low, with only 2 matched unrelated donor allo-HSCTs reported. One hundred umbilical cord blood transplantations were reported (0.017% of allo-HSCT). Peripheral blood stem cells were the main source of graft in allo-HSCT, and peripheral blood stem cells increasingly constitute the main source of hematopoietic stem cells overall. Reduced-intensity conditioning was utilized in 5.7% of allografts over the surveyed period. ASCT numbers continue to increase. There has been a shift in the indication for ASCT from acute leukemia to lymphoproliferative disorders (45%), followed by myeloma (26%). The survey reflects transplantation activity according to the unique health settings of this region. Notable differences in transplantation practices as reported to the European Group for Blood and Marrow Transplantation over recent years are highlighted.

Original languageEnglish
Pages (from-to)1352-1361
Number of pages10
JournalBiology of Blood and Marrow Transplantation
Issue number9
Publication statusPublished - Sept 2011


  • Conditioning
  • EMRO
  • Hematopoietic stem cell transplantation
  • Stem cell source


Dive into the research topics of 'Trends of hematopoietic stem cell transplantation in the Eastern Mediterranean region, 1984-2007'. Together they form a unique fingerprint.

Cite this