Two-Year Duration of Immunity of Inactivated Poliovirus Vaccine: A Follow-up Study in Pakistan in 2020

Ali Faisal Saleem; Sadia Parkar; Syeda Mahjabeen Zehra; Zaubina Kazi; Asma Pethani; Yiting Zhang; Bernardo A. Mainou; Rocio Lopez Cavestany; Grace MacKlin; Visalakshi Jeyaseelan; Ondrej Mach

doi:10.1093/infdis/jiad237

Two-Year Duration of Immunity of Inactivated Poliovirus Vaccine: A Follow-up Study in Pakistan in 2020

Ali Faisal Saleem
, Sadia Parkar
, Syeda Mahjabeen Zehra
, Zaubina Kazi
, Asma Pethani
, Yiting Zhang
, Bernardo A. Mainou
, Rocio Lopez Cavestany
, Grace MacKlin
, Visalakshi Jeyaseelan
, Ondrej Mach

Division of Woman and Child Health, Medical College, Pakistan
Department of Paediatrics and Child Health, Division of Woman and Child Health, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

Abstract

This was a follow-up study conducted in 2020 assessing changes in levels of type 2 poliovirus-neutralizing antibodies 2 years postimmunization in children who received inactivated poliovirus vaccine (IPV) in Karachi, Pakistan. Unexpectedly, the findings revealed an increase in seroprevalence of type 2 antibodies from 73.1% to 81.6% 1 year and 2 years after IPV, respectively. The increase in type 2 immunity could result from the intensive transmission of circulating vaccine-derived poliovirus type 2 (cVDPV2) in Karachi during the second year of IPV administration. This study suggests that the cVDPV2 outbreak detected in Pakistan infected large proportions of children in Karachi.

Original language	English (UK)
Pages (from-to)	39-42
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	229
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiad237
Publication status	Published - 15 Jan 2024

Keywords

Pakistan
duration of immunity
inactivated poliovirus vaccine
poliovirus
seroprevalence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jiad237

Cite this

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title = "Two-Year Duration of Immunity of Inactivated Poliovirus Vaccine: A Follow-up Study in Pakistan in 2020",

abstract = "This was a follow-up study conducted in 2020 assessing changes in levels of type 2 poliovirus-neutralizing antibodies 2 years postimmunization in children who received inactivated poliovirus vaccine (IPV) in Karachi, Pakistan. Unexpectedly, the findings revealed an increase in seroprevalence of type 2 antibodies from 73.1\% to 81.6\% 1 year and 2 years after IPV, respectively. The increase in type 2 immunity could result from the intensive transmission of circulating vaccine-derived poliovirus type 2 (cVDPV2) in Karachi during the second year of IPV administration. This study suggests that the cVDPV2 outbreak detected in Pakistan infected large proportions of children in Karachi.",

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author = "Saleem, \{Ali Faisal\} and Sadia Parkar and Zehra, \{Syeda Mahjabeen\} and Zaubina Kazi and Asma Pethani and Yiting Zhang and Mainou, \{Bernardo A.\} and \{Lopez Cavestany\}, Rocio and Grace MacKlin and Visalakshi Jeyaseelan and Ondrej Mach",

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doi = "10.1093/infdis/jiad237",

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AU - Saleem, Ali Faisal

AU - Parkar, Sadia

AU - Zehra, Syeda Mahjabeen

AU - Kazi, Zaubina

AU - Pethani, Asma

AU - Zhang, Yiting

AU - Mainou, Bernardo A.

AU - Lopez Cavestany, Rocio

AU - MacKlin, Grace

AU - Jeyaseelan, Visalakshi

AU - Mach, Ondrej

PY - 2024/1/15

Y1 - 2024/1/15

N2 - This was a follow-up study conducted in 2020 assessing changes in levels of type 2 poliovirus-neutralizing antibodies 2 years postimmunization in children who received inactivated poliovirus vaccine (IPV) in Karachi, Pakistan. Unexpectedly, the findings revealed an increase in seroprevalence of type 2 antibodies from 73.1% to 81.6% 1 year and 2 years after IPV, respectively. The increase in type 2 immunity could result from the intensive transmission of circulating vaccine-derived poliovirus type 2 (cVDPV2) in Karachi during the second year of IPV administration. This study suggests that the cVDPV2 outbreak detected in Pakistan infected large proportions of children in Karachi.

AB - This was a follow-up study conducted in 2020 assessing changes in levels of type 2 poliovirus-neutralizing antibodies 2 years postimmunization in children who received inactivated poliovirus vaccine (IPV) in Karachi, Pakistan. Unexpectedly, the findings revealed an increase in seroprevalence of type 2 antibodies from 73.1% to 81.6% 1 year and 2 years after IPV, respectively. The increase in type 2 immunity could result from the intensive transmission of circulating vaccine-derived poliovirus type 2 (cVDPV2) in Karachi during the second year of IPV administration. This study suggests that the cVDPV2 outbreak detected in Pakistan infected large proportions of children in Karachi.

KW - Pakistan

KW - duration of immunity

KW - inactivated poliovirus vaccine

KW - poliovirus

KW - seroprevalence

UR - https://www.scopus.com/pages/publications/85182501514

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M3 - Article

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AN - SCOPUS:85182501514

SN - 0022-1899

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JF - Journal of Infectious Diseases

IS - 1

ER -

Two-Year Duration of Immunity of Inactivated Poliovirus Vaccine: A Follow-up Study in Pakistan in 2020

Abstract

Keywords

UN SDGs

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