Update on associated risk factors, diagnosis, and management of recurrent urinary tract infections in children

Anum Khan, Ravi Jhaveri, Patrick C. Seed, Mehreen Arshad

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Recurrent urinary tract infection (rUTI) continues to challenge pediatric care providers. The diagnosis of an rUTI can be difficult, especially in young febrile children. Antibiotic resistance rates continue to rise, which limits oral treatment options. Prophylactic antibiotics are used commonly to manage rUTI, but their use increases the risk of rUTI with antibiotic-resistant strains without significantly reducing renal scarring. Alternative therapies for rUTI include probiotics and anthocyanidins (eg, cranberry extract) to reduce gut colonization by uropathogens and prevent bacterial adhesion to uroepithelia, but efficacy data for these treatments are sparse. The future of rUTI care rests in addressing the following contemporary issues: best diagnostic practices, risk factors associated with rUTI, and the prevention of recurrent infection. In this review, we summarize the state of the art for each of these issues and highlight future studies that will aim to take an alternative approach to managing rUTI.

Original languageEnglish
Pages (from-to)152-159
Number of pages8
JournalJournal of the Pediatric Infectious Diseases Society
Volume8
Issue number2
DOIs
Publication statusPublished - 11 May 2019
Externally publishedYes

Keywords

  • Antibiotic resistance
  • Diagnosis
  • Probiotics
  • Recurrent UTI

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