Upper gastrointestinal lesions in chronic renal failure and the frequency of helicobacter pylori

Aly Haider Badruddin, Zaigham Abbas, Naila Tariq

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Objective: To highlight the commonest upper gastrointestinal (UGI) lesions in patients with chronic renal failure (CRF) and compare it to a control group of patients with symptoms of UGI disease without renal disease. And also to determine the prevalence of Helicobacter pylori (HP) infection in both groups of patients. Design: A case-control prospective study. Place and Duration of Study: The Department of Nephrology, and the Departments of Gastroenterology and Pathology, Medical Unit III, Jinnah Postgraduate Medical Centre, Karachi. (Pakistan). Study conducted over a period of two years (01-01-97 to 31-12-98). Patients and Methods: One hundred consecutive patients divided into two equal groups, those with CRF with or without symptoms of acid peptic disease (the study group), and the other (the control group) had symptoms of UGI disease with no evidence of renal disease. The stages of CRF, symptoms of acid peptic disease, type of UGI lesions, and the presence or absence of Helicobacter pylori (HP) were noted. Results: The commonest UGI lesions in patients of CRF were gastric erosions 17(34%) followed by inflammatory lesions 16(32%), the incidence increasing with the severity of the renal disease. In the control group 20(42%) had gastric erosions and 17 (34%) had inflammatory lesions. HP infection occured in 76-83% of patients in the study group, and in the control group it was found in 75-88% of patients. Conclusion: In both groups the commonest UGI lesions were gastric erosions, followed by inflammatory lesions mainly gastritis and esophagitis. These lesions occurred more frequently with increasing severity of renal disease. HP infection was common in both groups almost equally.

Original languageEnglish
Pages (from-to)102-104
Number of pages3
JournalJournal of the College of Physicians and Surgeons--Pakistan : JCPSP
Issue number2
Publication statusPublished - 2002
Externally publishedYes


  • Chronic
  • Esophagitis
  • Gastritis
  • Gastrointestinal diseases
  • Helicobacter pylori (HP)
  • Kidney failure


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