@article{f961e8a0914c4a3891634c92ba8fbaab,
title = "Urgently seeking efficiency and sustainability of clinical trials in global health",
abstract = "This paper shows the scale of global health research and the context in which we frame the subsequent papers in the Series. In this Series paper, we provide a historical perspective on clinical trial research by revisiting the 1948 streptomycin trial for pulmonary tuberculosis, which was the first documented randomised clinical trial in the English language, and we discuss its close connection with global health. We describe the current state of clinical trial research globally by providing an overview of clinical trials that have been registered in the WHO International Clinical Trial Registry since 2010. We discuss challenges with current trial planning and designs that are often used in clinical trial research undertaken in low-income and middle-income countries, as an overview of the global health trials landscape. Finally, we discuss the importance of collaborative work in global health research towards generating sustainable and culturally appropriate research environments.",
author = "Park, {Jay J.H.} and Grais, {Rebecca F.} and Monica Taljaard and Etheldreda Nakimuli-Mpungu and Fyezah Jehan and Nachega, {Jean B.} and Nathan Ford and Denis Xavier and Kengne, {Andre P.} and Per Ashorn and Socias, {Maria Eugenia} and Bhutta, {Zulfiqar A.} and Mills, {Edward J.}",
note = "Funding Information: This Series was supported by the Bill & Melinda Gates Foundation. No authors received funding, and all authors volunteered their time. The funding source had no role in the design and implementation of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the paper; and decision to submit the paper for publication. The funding provided by the Gates Foundation was used for administrative support to coordinate submission efforts. The contents of the paper are the sole responsibility of the authors and might not necessarily represent the official views of the Gates Foundation or other agencies that might have supported the primary data studies used in the present study. The corresponding author (EJM) had the final responsibility for the decision to submit for publication. Publisher Copyright: {\textcopyright} 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license",
year = "2021",
month = may,
doi = "10.1016/S2214-109X(20)30539-8",
language = "English",
volume = "9",
pages = "e681--e690",
journal = "The Lancet Global Health",
issn = "2214-109X",
publisher = "Elsevier BV",
number = "5",
}
