Urgently seeking efficiency and sustainability of clinical trials in global health

Jay J.H. Park; Rebecca F. Grais; Monica Taljaard; Etheldreda Nakimuli-Mpungu; Fyezah Jehan; Jean B. Nachega; Nathan Ford; Denis Xavier; Andre P. Kengne; Per Ashorn; Maria Eugenia Socias; Zulfiqar A. Bhutta; Edward J. Mills

doi:10.1016/S2214-109X(20)30539-8

Urgently seeking efficiency and sustainability of clinical trials in global health

Jay J.H. Park, Rebecca F. Grais, Monica Taljaard, Etheldreda Nakimuli-Mpungu, Fyezah Jehan, Jean B. Nachega, Nathan Ford, Denis Xavier, Andre P. Kengne, Per Ashorn, Maria Eugenia Socias, Zulfiqar A. Bhutta, Edward J. Mills

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

This paper shows the scale of global health research and the context in which we frame the subsequent papers in the Series. In this Series paper, we provide a historical perspective on clinical trial research by revisiting the 1948 streptomycin trial for pulmonary tuberculosis, which was the first documented randomised clinical trial in the English language, and we discuss its close connection with global health. We describe the current state of clinical trial research globally by providing an overview of clinical trials that have been registered in the WHO International Clinical Trial Registry since 2010. We discuss challenges with current trial planning and designs that are often used in clinical trial research undertaken in low-income and middle-income countries, as an overview of the global health trials landscape. Finally, we discuss the importance of collaborative work in global health research towards generating sustainable and culturally appropriate research environments.

Original language	English
Pages (from-to)	e681-e690
Journal	The Lancet Global Health
Volume	9
Issue number	5
DOIs	https://doi.org/10.1016/S2214-109X(20)30539-8
Publication status	Published - May 2021

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10.1016/S2214-109X(20)30539-8

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title = "Urgently seeking efficiency and sustainability of clinical trials in global health",

abstract = "This paper shows the scale of global health research and the context in which we frame the subsequent papers in the Series. In this Series paper, we provide a historical perspective on clinical trial research by revisiting the 1948 streptomycin trial for pulmonary tuberculosis, which was the first documented randomised clinical trial in the English language, and we discuss its close connection with global health. We describe the current state of clinical trial research globally by providing an overview of clinical trials that have been registered in the WHO International Clinical Trial Registry since 2010. We discuss challenges with current trial planning and designs that are often used in clinical trial research undertaken in low-income and middle-income countries, as an overview of the global health trials landscape. Finally, we discuss the importance of collaborative work in global health research towards generating sustainable and culturally appropriate research environments.",

author = "Park, {Jay J.H.} and Grais, {Rebecca F.} and Monica Taljaard and Etheldreda Nakimuli-Mpungu and Fyezah Jehan and Nachega, {Jean B.} and Nathan Ford and Denis Xavier and Kengne, {Andre P.} and Per Ashorn and Socias, {Maria Eugenia} and Bhutta, {Zulfiqar A.} and Mills, {Edward J.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license",

year = "2021",

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doi = "10.1016/S2214-109X(20)30539-8",

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AU - Grais, Rebecca F.

AU - Taljaard, Monica

AU - Nakimuli-Mpungu, Etheldreda

AU - Jehan, Fyezah

AU - Nachega, Jean B.

AU - Ford, Nathan

AU - Xavier, Denis

AU - Kengne, Andre P.

AU - Ashorn, Per

AU - Socias, Maria Eugenia

AU - Bhutta, Zulfiqar A.

AU - Mills, Edward J.

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AB - This paper shows the scale of global health research and the context in which we frame the subsequent papers in the Series. In this Series paper, we provide a historical perspective on clinical trial research by revisiting the 1948 streptomycin trial for pulmonary tuberculosis, which was the first documented randomised clinical trial in the English language, and we discuss its close connection with global health. We describe the current state of clinical trial research globally by providing an overview of clinical trials that have been registered in the WHO International Clinical Trial Registry since 2010. We discuss challenges with current trial planning and designs that are often used in clinical trial research undertaken in low-income and middle-income countries, as an overview of the global health trials landscape. Finally, we discuss the importance of collaborative work in global health research towards generating sustainable and culturally appropriate research environments.

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Urgently seeking efficiency and sustainability of clinical trials in global health

Abstract

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