Use of ISTH bleeding assessment tool to predict inherited platelet dysfunction in resource constrained settings

Anila Rashid, Bushra Moiz, Farheen Karim, Muhammad Shariq Shaikh, Huma Mansoori, Ahmed Raheem

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Background: The International Society of Thrombosis & Hemostasis (ISTH) bleeding assessment tool (ISTH-BAT) is used to record bleeding symptoms in patients with possible bleeding disorders. Aim: To investigate the utility of the ISTH-BAT in predicting platelet dysfunction in individuals with suspected inherited platelet function disorders. Method: Individuals with clinical evidence of bleeding and suspected inherited platelet function disorder and healthy volunteers were included in the study. The ISTH-BAT questionnaire was applied prior to light transmission aggregometry (LTA). Results: A total of 261 participants were included (100 healthy volunteers, and 161 with suspected inherited platelet function disorders). The ISTH-BAT score in participants with suspected inherited platelet function disorders (median 2; interquartile range [IQR] 5–1) was significantly higher than in healthy volunteers (median 0; IQR 2–0). There was also a significant difference between participants with suspected inherited platelet function disorders with a platelet defect detected by LTA (median 4; IQR 8–3) and those with normal platelet function (median 2; IQR 3–1) (p < 0.001). The ISTH-BAT score was associated with a demonstrable platelet defect on platelet function testing (area under the receiver operating characteristic curve = 0.8 [95% confidence interval 0.72–0.87, p = < 0.001] and odds ratio 3.25 [95% confidence interval 2.13–4.37, p = < 0.001]). Conclusion: The ISTH-BAT is a useful tool for documenting bleeding symptoms and the score obtained is also predictive of the presence of a platelet defect on LTA in patients with suspected inherited platelet dysfunction.

Original languageEnglish
Pages (from-to)373-378
Number of pages6
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume76
Issue number5
DOIs
Publication statusPublished - 3 Jul 2016

Keywords

  • Bleeding score
  • bleeding assessment tools
  • inherited platelet disorders
  • light transmission aggregometry
  • platelet aggregation
  • platelet function

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