Utility of post mastectomy radiotherapy among patients with T1/ T2 N1 disease: A retrospective cohort study

Lubna M. Vohra; Rufina Soomro; Dua Jabeen; Nasir Ali; Nargis Khan

doi:10.1016/j.amsu.2021.102295

Utility of post mastectomy radiotherapy among patients with T1/ T2 N1 disease: A retrospective cohort study

Lubna M. Vohra, Rufina Soomro, Dua Jabeen, Nasir Ali, Nargis Khan

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Abstract

Background: Pakistan has the highest incidence of breast cancer among Asian Countries but there is insufficient representation of local data addressing breast cancer treatment and outcome. We sought to determine the role of post-mastectomy radiotherapy (PMRT) in T1- T2 breast cancer with 1–3 positive axillary lymph nodes. Methods: Data was reviewed retrospectively of total 755 patients out of which 291 received PMRT and 464 did not from two large breast cancer centres. Results: With a median follow up of 78 months, 4 (4.5%) patients developed loco regional recurrence (LRR) in the PMRT group while a substantial number 74 (24.4%) recurred in the non PMRT group (p = 0.000). Loco regional free survival rate (LRFS) and overall survival rate (OS) was significantly better for PMRT patients than non-PMRT patients (P = <0.000). Multivariate analysis identified young age, lymphovascular invasion, extra capsular extension, triple negative and ER/PR negative were independent prognostic factors affecting loco regional free survival (LRFS). Conclusion: Disease recurrence is a substantial issue in 1–3 node group despite early stage, PMRT has an instrumental effect in improving LRFS and OS.

Original language	English
Article number	102295
Journal	Annals of Medicine and Surgery
Volume	65
DOIs	https://doi.org/10.1016/j.amsu.2021.102295
Publication status	Published - May 2021

Keywords

Breast cancer
Lymph nodes
Mastectomy
Patients
Radiotherapy
Recurrence
Survival

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10.1016/j.amsu.2021.102295

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@article{ada97c612e1b48a393c59d08c260114e,

title = "Utility of post mastectomy radiotherapy among patients with T1/ T2 N1 disease: A retrospective cohort study",

abstract = "Background: Pakistan has the highest incidence of breast cancer among Asian Countries but there is insufficient representation of local data addressing breast cancer treatment and outcome. We sought to determine the role of post-mastectomy radiotherapy (PMRT) in T1- T2 breast cancer with 1–3 positive axillary lymph nodes. Methods: Data was reviewed retrospectively of total 755 patients out of which 291 received PMRT and 464 did not from two large breast cancer centres. Results: With a median follow up of 78 months, 4 (4.5%) patients developed loco regional recurrence (LRR) in the PMRT group while a substantial number 74 (24.4%) recurred in the non PMRT group (p = 0.000). Loco regional free survival rate (LRFS) and overall survival rate (OS) was significantly better for PMRT patients than non-PMRT patients (P = <0.000). Multivariate analysis identified young age, lymphovascular invasion, extra capsular extension, triple negative and ER/PR negative were independent prognostic factors affecting loco regional free survival (LRFS). Conclusion: Disease recurrence is a substantial issue in 1–3 node group despite early stage, PMRT has an instrumental effect in improving LRFS and OS.",

keywords = "Breast cancer, Lymph nodes, Mastectomy, Patients, Radiotherapy, Recurrence, Survival",

author = "Vohra, {Lubna M.} and Rufina Soomro and Dua Jabeen and Nasir Ali and Nargis Khan",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2021",

month = may,

doi = "10.1016/j.amsu.2021.102295",

language = "English",

volume = "65",

journal = "Annals of Medicine and Surgery",

issn = "2049-0801",

publisher = "Elsevier BV",

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TY - JOUR

T1 - Utility of post mastectomy radiotherapy among patients with T1/ T2 N1 disease

T2 - A retrospective cohort study

AU - Vohra, Lubna M.

AU - Soomro, Rufina

AU - Jabeen, Dua

AU - Ali, Nasir

AU - Khan, Nargis

PY - 2021/5

Y1 - 2021/5

N2 - Background: Pakistan has the highest incidence of breast cancer among Asian Countries but there is insufficient representation of local data addressing breast cancer treatment and outcome. We sought to determine the role of post-mastectomy radiotherapy (PMRT) in T1- T2 breast cancer with 1–3 positive axillary lymph nodes. Methods: Data was reviewed retrospectively of total 755 patients out of which 291 received PMRT and 464 did not from two large breast cancer centres. Results: With a median follow up of 78 months, 4 (4.5%) patients developed loco regional recurrence (LRR) in the PMRT group while a substantial number 74 (24.4%) recurred in the non PMRT group (p = 0.000). Loco regional free survival rate (LRFS) and overall survival rate (OS) was significantly better for PMRT patients than non-PMRT patients (P = <0.000). Multivariate analysis identified young age, lymphovascular invasion, extra capsular extension, triple negative and ER/PR negative were independent prognostic factors affecting loco regional free survival (LRFS). Conclusion: Disease recurrence is a substantial issue in 1–3 node group despite early stage, PMRT has an instrumental effect in improving LRFS and OS.

AB - Background: Pakistan has the highest incidence of breast cancer among Asian Countries but there is insufficient representation of local data addressing breast cancer treatment and outcome. We sought to determine the role of post-mastectomy radiotherapy (PMRT) in T1- T2 breast cancer with 1–3 positive axillary lymph nodes. Methods: Data was reviewed retrospectively of total 755 patients out of which 291 received PMRT and 464 did not from two large breast cancer centres. Results: With a median follow up of 78 months, 4 (4.5%) patients developed loco regional recurrence (LRR) in the PMRT group while a substantial number 74 (24.4%) recurred in the non PMRT group (p = 0.000). Loco regional free survival rate (LRFS) and overall survival rate (OS) was significantly better for PMRT patients than non-PMRT patients (P = <0.000). Multivariate analysis identified young age, lymphovascular invasion, extra capsular extension, triple negative and ER/PR negative were independent prognostic factors affecting loco regional free survival (LRFS). Conclusion: Disease recurrence is a substantial issue in 1–3 node group despite early stage, PMRT has an instrumental effect in improving LRFS and OS.

KW - Breast cancer

KW - Lymph nodes

KW - Mastectomy

KW - Patients

KW - Radiotherapy

KW - Recurrence

KW - Survival

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DO - 10.1016/j.amsu.2021.102295

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AN - SCOPUS:85104418210

SN - 2049-0801

VL - 65

JO - Annals of Medicine and Surgery

JF - Annals of Medicine and Surgery

M1 - 102295

ER -

Utility of post mastectomy radiotherapy among patients with T1/ T2 N1 disease: A retrospective cohort study

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Keywords

UN SDGs

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