Variable drug metabolism genes in Arab population

R. Bu; M. I. Gutiérrez; M. Al-Rasheed; A. Belgaumi; Kishor Bhatia

doi:10.1038/sj.tpj.6500251

Variable drug metabolism genes in Arab population

R. Bu, M. I. Gutiérrez, M. Al-Rasheed, A. Belgaumi, Kishor Bhatia

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Cataloging interethnic differences in the distribution of genotypes of drug metabolic genes provides valuable information for profiling the pharmacogenetics of a population. We used PCR analysis to catalog the frequencies of alleles and genotypes for CYP1A1, NAT2, GSTs, MTHFR, MTR (MS) and NQO*1 in Arabs. The frequencies of alleles and/or genotypes for CYP1A1*2A, GSTT1 null, GSTT1 and GSTM1 double null, and GSTP1 A1578G in Arabs were significantly higher than those reported in Caucasians. However, the distribution of NAT2 acetylator phenotypes in both populations was similar. In contrast, the frequencies of MTHFR 677T allele and the combined (677 + 1298) genotypes for low activity were lower than those reported in Caucasians. Other alleles in Arabs, including CYP1A1 T3801C and GSTP1 A1578G were present in frequencies similar to Africans. The overall profile of variations in metabolism genes in Arabs is thus unique.

Original language	English
Pages (from-to)	260-266
Number of pages	7
Journal	Pharmacogenomics Journal
Volume	4
Issue number	4
DOIs	https://doi.org/10.1038/sj.tpj.6500251
Publication status	Published - 2004
Externally published	Yes

Keywords

CYP1A1
GSTs
Genetic polymorphism
MTHFR
MTR (MS)
NAT2
NQO*1
Population genetic structure
Risk of cancer
Toxicity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.tpj.6500251

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title = "Variable drug metabolism genes in Arab population",

abstract = "Cataloging interethnic differences in the distribution of genotypes of drug metabolic genes provides valuable information for profiling the pharmacogenetics of a population. We used PCR analysis to catalog the frequencies of alleles and genotypes for CYP1A1, NAT2, GSTs, MTHFR, MTR (MS) and NQO*1 in Arabs. The frequencies of alleles and/or genotypes for CYP1A1*2A, GSTT1 null, GSTT1 and GSTM1 double null, and GSTP1 A1578G in Arabs were significantly higher than those reported in Caucasians. However, the distribution of NAT2 acetylator phenotypes in both populations was similar. In contrast, the frequencies of MTHFR 677T allele and the combined (677 + 1298) genotypes for low activity were lower than those reported in Caucasians. Other alleles in Arabs, including CYP1A1 T3801C and GSTP1 A1578G were present in frequencies similar to Africans. The overall profile of variations in metabolism genes in Arabs is thus unique.",

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AU - Bu, R.

AU - Gutiérrez, M. I.

AU - Al-Rasheed, M.

AU - Belgaumi, A.

AU - Bhatia, Kishor

PY - 2004

Y1 - 2004

N2 - Cataloging interethnic differences in the distribution of genotypes of drug metabolic genes provides valuable information for profiling the pharmacogenetics of a population. We used PCR analysis to catalog the frequencies of alleles and genotypes for CYP1A1, NAT2, GSTs, MTHFR, MTR (MS) and NQO*1 in Arabs. The frequencies of alleles and/or genotypes for CYP1A1*2A, GSTT1 null, GSTT1 and GSTM1 double null, and GSTP1 A1578G in Arabs were significantly higher than those reported in Caucasians. However, the distribution of NAT2 acetylator phenotypes in both populations was similar. In contrast, the frequencies of MTHFR 677T allele and the combined (677 + 1298) genotypes for low activity were lower than those reported in Caucasians. Other alleles in Arabs, including CYP1A1 T3801C and GSTP1 A1578G were present in frequencies similar to Africans. The overall profile of variations in metabolism genes in Arabs is thus unique.

AB - Cataloging interethnic differences in the distribution of genotypes of drug metabolic genes provides valuable information for profiling the pharmacogenetics of a population. We used PCR analysis to catalog the frequencies of alleles and genotypes for CYP1A1, NAT2, GSTs, MTHFR, MTR (MS) and NQO*1 in Arabs. The frequencies of alleles and/or genotypes for CYP1A1*2A, GSTT1 null, GSTT1 and GSTM1 double null, and GSTP1 A1578G in Arabs were significantly higher than those reported in Caucasians. However, the distribution of NAT2 acetylator phenotypes in both populations was similar. In contrast, the frequencies of MTHFR 677T allele and the combined (677 + 1298) genotypes for low activity were lower than those reported in Caucasians. Other alleles in Arabs, including CYP1A1 T3801C and GSTP1 A1578G were present in frequencies similar to Africans. The overall profile of variations in metabolism genes in Arabs is thus unique.

KW - CYP1A1

KW - GSTs

KW - Genetic polymorphism

KW - MTHFR

KW - MTR (MS)

KW - NAT2

KW - NQO1

KW - Population genetic structure

KW - Risk of cancer

KW - Toxicity

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VL - 4

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EP - 266

JO - Pharmacogenomics Journal

JF - Pharmacogenomics Journal

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ER -

Variable drug metabolism genes in Arab population

Abstract

Keywords

UN SDGs

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