Ventricular peptides and cardiac function

Seventeen and a half million deaths occur every year due to cardiovascular diseases across the world and one in three deaths in the world are caused by cardiovascular diseases such as, heart attack or heart failure according to WHO. Improved diagnosis and risk stratification of patients with the left ventricular dysfunction can help in preventing the major cause of death. This article review was the results of recent clinical studies relating to various heart diseases with the ventricular cardiac peptides such as B-type natriuretic peptide (BNP) and amino terminal B-type natriuretic peptide (NT-proBNP) levels as potential markers of diastolic and systolic left ventricular dysfunction. Sources of Data/Study selection: Data from survey reports, descriptive, cross-sectional and longitudinal studies published between 1981-2011 on the topic were included. Data searches based on human and animal studies were included. Data Extraction: The data was extracted from online resources of World Heart Failure Society, Heart Failure Society of America, World Heart Federation, The MEDLINE, the internet (e-medicine, medscape resource centre). Conclusion: Analysis of these ventricular peptides appears to be a potential approach for elucidation of the pathophysiology of the heart.