Viral etiology of prostate cancer: Genetic alterations and immune response. A literature review

Syed Hani Abidi, Fareena Bilwani, Kulsoom Ghias, Farhat Abbas

Research output: Contribution to journalReview articlepeer-review

21 Citations (Scopus)

Abstract

Prostate cancer is one of the most common cancers in men. Recent estimates suggest that over a million men are diagnosed with the disease annually. Prostate cancer pathogenesis involves both heritable and environmental factors. The molecular events involved in the development or progression of prostate cancer are still unclear. Recent body of literature highlights the role of viral infections in initiation or progression of prostate cancer. In this regard, certain viruses have been reported to interact with host proteins and bring about changes in genetic, immunological and inflammatory events that lead to initiation or progression of prostate cancer. We conducted a comprehensive PubMed database search to identify publications relevant to viruses associated with prostate cancer. In this review, we discuss the possible viral etiology of prostate cancer and evidence of viral-mediated genetic changes, and immune dysregulation involved in initiation or progression of prostate cancer.

Original languageEnglish
Pages (from-to)136-140
Number of pages5
JournalInternational Journal of Surgery
Volume52
DOIs
Publication statusPublished - Apr 2018

Keywords

  • Genetic
  • Immune system
  • Prostate cancer
  • Virus

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