Vitamin D deficiency in ambulatory patients

Lubna M. Zuberi, Aysha Habib, Naeemul Haque, Abdul Jabbar

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


Objective: To determine the frequency of subclinical vitamin D deficiency in an ambulatory care setting. Methods: This was an observational study which measured 25 vitamin D levels in medical clinic patients. Patients with chronic renal failure, known osteomalacia and rickets were excluded. A total of 119 patients were evaluated. They were divided in three diagnostic categories based on their serum 25 vitamin D levels. Those with levels below 8 ng/ml were categorized to have severe deficiency, levels between 8 - 20 ng/ml as moderate deficiency and levels of 21 - 35 mg/ml as mild deficiency. Results: Of 119 patients, 92% had vitamin D deficiency. Their mean age was 44.3 ± 18.3 years, with female to male ratio of 5:1 .Sixty two percent (62%) had severe, 24% moderate and 8% had mild deficiency. Nearly half of all these patients (including those with severe deficiency) were asymptomatic. Whereas a low serum calcium, elevated phosphate and elevated alkaline phosphatase were reflective of severe deficiency. It was only an elevated iPTH that correlated with mild to moderate deficiency. Conclusion: Subclinical vitamin D deficiency is extensive in the adult ambulatory care patients. Serum calcium, phosphate and alkaline phosphatase are poor markers of moderate to mild deficiency. A serum 25 vitamin D level and an iPTH are better biofunctional markers of this deficiency (JPMA 58:482;2008).

Original languageEnglish
Pages (from-to)482-484
Number of pages3
JournalJournal of the Pakistan Medical Association
Issue number9
Publication statusPublished - Sept 2008


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