Vitamin E deficiency and platelet functional defect in a jaundiced infant

Mohammad Khurshid; T J Lee; I R Peake; A L Bloom

Vitamin E deficiency and platelet functional defect in a jaundiced infant

Mohammad Khurshid, T J Lee, I R Peake, A L Bloom

Section of Haematology/Oncology, Department of Medicine, Medical College, Pakistan

Research output: Contribution to journal › Article

Abstract

A 16-month-old infant with hepatic fibrosis, cholestasis, and chronic jaundice had signs of vitamin E deficiency, including mild acanthocytosis, thrombocytosis, increased peroxide haemolysis, and absent serum vitamin E. Abormal prothrombin consumption and platelet restocetin aggregation suggested the presence of defective platelet function, and correction studies indicated that this was due to a plasma defect. The abnormality was corrected by treatment with vitamin E, and the findings suggest a possible role of this vitamin in platelet reactions.

Original language	Undefined/Unknown
Journal	Section of Haematology/Oncology
Publication status	Published - 1 Jan 1975

Access to Document

http://ecommons.aku.edu/pakistan_fhs_mc_med_haematol_oncol/29

Cite this

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title = "Vitamin E deficiency and platelet functional defect in a jaundiced infant",

abstract = "A 16-month-old infant with hepatic fibrosis, cholestasis, and chronic jaundice had signs of vitamin E deficiency, including mild acanthocytosis, thrombocytosis, increased peroxide haemolysis, and absent serum vitamin E. Abormal prothrombin consumption and platelet restocetin aggregation suggested the presence of defective platelet function, and correction studies indicated that this was due to a plasma defect. The abnormality was corrected by treatment with vitamin E, and the findings suggest a possible role of this vitamin in platelet reactions.",

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T1 - Vitamin E deficiency and platelet functional defect in a jaundiced infant

AU - Khurshid, Mohammad

AU - Lee, T J

AU - Peake, I R

AU - Bloom, A L

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Y1 - 1975/1/1

N2 - A 16-month-old infant with hepatic fibrosis, cholestasis, and chronic jaundice had signs of vitamin E deficiency, including mild acanthocytosis, thrombocytosis, increased peroxide haemolysis, and absent serum vitamin E. Abormal prothrombin consumption and platelet restocetin aggregation suggested the presence of defective platelet function, and correction studies indicated that this was due to a plasma defect. The abnormality was corrected by treatment with vitamin E, and the findings suggest a possible role of this vitamin in platelet reactions.

AB - A 16-month-old infant with hepatic fibrosis, cholestasis, and chronic jaundice had signs of vitamin E deficiency, including mild acanthocytosis, thrombocytosis, increased peroxide haemolysis, and absent serum vitamin E. Abormal prothrombin consumption and platelet restocetin aggregation suggested the presence of defective platelet function, and correction studies indicated that this was due to a plasma defect. The abnormality was corrected by treatment with vitamin E, and the findings suggest a possible role of this vitamin in platelet reactions.

M3 - Article

JO - Section of Haematology/Oncology

JF - Section of Haematology/Oncology

ER -