Vitamin E deficiency in south asian population and the therapeutic use of alpha-tocopherol (Vitamin E) for correction of anemia

Tanveer Jilani, Mohammad Perwaiz Iqbal

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Mild to moderate vitamin E deficiency because of inadequate consumption of vitamin E-rich foods and intestinal fat malabsorption is common in growing children, women of reproductive age and elderly South Asian population. Severe vitamin E deficiency may lead to peripheral and motor neurodegenerative diseases (e.g ataxia and motor skeletal myopathy), impaired immune response and free radical-induced hemolytic anemias. Vitamin E insufficiency and/or deficiency status in the general Pakistani population has not been sufficiently investigated. Moreover, there are challenges in determining vitamin E status in apparently healthy humans due to variations in their age, sources of consumed vitamin E and plasma lipid levels. Oxidative stress-induced reactive oxygen species have been shown to cause ineffective erythropoiesis and enhanced lysis of erythrocytes in some of the experimental animals and humans. Several studies on patients with various types of inherited hemolytic anemias, chronic renal disease, premature low birth infants and apparently healthy humans have shown that vitamin E might be therapeutically effective in the prevention and/ or treatment of anemia in these subjects.

Original languageEnglish
Pages (from-to)1571-1575
Number of pages5
JournalPakistan Journal of Medical Sciences
Volume34
Issue number6
DOIs
Publication statusPublished - 1 Nov 2018

Keywords

  • Alpha tocopherol
  • Anemia
  • South asian population
  • Vitamin E deficiency

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