Waldenstrom's macroglobulinemia terminating in acute myeloid leukemia

Safoorah Khalid, Salman Naseem Adi, Mohammad Khurshid

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1 Citation (Scopus)


Waldenstrom's macroglobulinemia (WM) is a rare condition, accounting for approximately 2% of haematologic malignancies. The most common causes of death in these patients are progression of the malignant lymphoproliferative process, infection and cardiac failure. Acute leukemia is a rare event in the clinical course of WM. A number of case reports have documented the development of terminal acute leukemia in patients with WM following prolonged chemotherapy. We describe a case of an elderly man who was a diagnosed case of WM and treated with chlorambucil and cyclophosphamide. Four years later, he developed acute leukemia.

Original languageEnglish
Pages (from-to)291
Number of pages1
JournalJournal of the Pakistan Medical Association
Issue number6
Publication statusPublished - Jun 2006


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