Whipple's disease

Syed Mudassir Laeeq, Nasir Hassan Luck, Syed Mujahid Hassan, Zaigham Abbas, Abbas Ali Tasneem, Muhammed Mubarak

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Whipple's disease is a rare chronic multi-systemic infection, caused by Gram-positive bacillus Tropheryma whipplei. The infection usually involves the small bowel, but other organs may also be involved. The diagnosis is often challenging and can only be made on histopathological examination. This report describes 2 patients presenting with abdominal pain and weight loss who finally were diagnosed to have Whipple's disease. One of the patients was a renal transplant recipient. To the best of authors' knowledge, no case of Whipple's disease has yet been reported in Pakistan. The diagnosis were made on the basis of histopathological evaluation of duodenal biopsies. The cases underscore the need for diligent histopathological evaluation of the upper gastrointestinal biopsies and a high index of suspicion for an accurate diagnosis of the condition. The approach to the diagnosis and management of the condition is discussed.

Original languageEnglish
Pages (from-to)S81-S83
JournalJournal of the College of Physicians and Surgeons--Pakistan : JCPSP
Publication statusPublished - 2014
Externally publishedYes


  • Malabsorption
  • PAS (periodic acid schiff) stain
  • Whipple's disease


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