TY - JOUR
T1 - Yttrium 90 ibritumomab tiuxetan radioimmunotherapy for relapsed or refractory low-grade non-hodgkin's lymphoma
AU - Gordon, Leo I.
AU - Witzig, Thomas E.
AU - Wiseman, Greg A.
AU - Flinn, Ian W.
AU - Spies, Stewart S.
AU - Silverman, Daniel H.
AU - Emmanuolides, Christos
AU - Cripe, Larry
AU - Saleh, Mansoor
AU - Czuczman, Myron S.
AU - Olejnik, Teresa
AU - White, Christine A.
AU - Grillo-López, Antonio J.
PY - 2002
Y1 - 2002
N2 - The treatment of malignant lymphoma has improved over the past 20 years, but the majority of patients are not cured. New modalities using targeted therapy based on new information in molecular biology and immunology hold promise for better outcomes with less toxicity. We review data on the use of radiolabeled monoclonal antibodies directed against the CD20 antigen on malignant B cells. We discuss the major radionuclides available, iodine 131 (131I), tositumomab, and yttrium 90 (90Y) ibritumomab tiuxetan (Zevalin; IDEC Pharmaceuticals, San Diego, CA) and present data on new approaches in labeling antibodies that have facilitated their use. Clinical trial data with the yttrium-labeled antibodies are discussed. The use of dosimetry as a means for predicting toxicity is discussed, and the questions of long-term toxicity (late effects) are addressed. These targeted approaches to the treatment of malignancy, and lymphoma in particular, hold great promise.
AB - The treatment of malignant lymphoma has improved over the past 20 years, but the majority of patients are not cured. New modalities using targeted therapy based on new information in molecular biology and immunology hold promise for better outcomes with less toxicity. We review data on the use of radiolabeled monoclonal antibodies directed against the CD20 antigen on malignant B cells. We discuss the major radionuclides available, iodine 131 (131I), tositumomab, and yttrium 90 (90Y) ibritumomab tiuxetan (Zevalin; IDEC Pharmaceuticals, San Diego, CA) and present data on new approaches in labeling antibodies that have facilitated their use. Clinical trial data with the yttrium-labeled antibodies are discussed. The use of dosimetry as a means for predicting toxicity is discussed, and the questions of long-term toxicity (late effects) are addressed. These targeted approaches to the treatment of malignancy, and lymphoma in particular, hold great promise.
UR - http://www.scopus.com/inward/record.url?scp=0036180910&partnerID=8YFLogxK
U2 - 10.1053/sonc.2002.30148
DO - 10.1053/sonc.2002.30148
M3 - Article
C2 - 11842394
AN - SCOPUS:0036180910
SN - 0093-7754
VL - 29
SP - 87
EP - 92
JO - Seminars in Oncology
JF - Seminars in Oncology
IS - 1 SUPPL. 2
ER -